DNA Microarrays and Gene Expression: From Experiments to Data Analysis and Modeling

Description

Massive data acquisition technologies, such as genome sequencing, high-throughput drug screening, and DNA arrays are in the process of revolutionizing biology and medicine. Using the mRNA of a given cell, at a given time, under a given set of conditions, DNA microarrays can provide a snapshot of the level of expression of all the genes in the cell. Such snapshots can be used to study fundamental biological phenomena such as development or evolution, to determine the function of new genes, to infer the role individual genes or groups of genes may play in diseases, and to monitor the effect of drugs and other compounds on gene expression. Originally published in 2002, this inter-disciplinary introduction to DNA arrays will be of value to anyone with an a interest in this powerful technology.

Review of the hardback: 'The book, written by Baldi and Hatfield, is an important and timely addition to the DNA microarray literature ... the first several chapters of the book provide an easy-to-digest overview of the current state of DNA microarrays.' Briefings in Functional Genomics & Proteomics Review of the hardback: 'Writing a book such as this was a challenging remit and one that the authors have achieved with great success.' Human Genomics Review of the hardback: 'I recommend very highly this book to statisticians in particular.' Journal of Statistical Computation & Simulation