Protein Condensation: Kinetic Pathways to Crystallization and Disease

Hardback

Main Details

Title Protein Condensation: Kinetic Pathways to Crystallization and Disease
Authors and Contributors      By (author) James D. Gunton
By (author) Andrey Shiryayev
By (author) Daniel L. Pagan
Physical Properties
Format:Hardback
Pages:376
Dimensions(mm): Height 250,Width 175
Category/GenreCellular biology (cytology)
ISBN/Barcode 9780521851213
ClassificationsDewey:572.633
Audience
Professional & Vocational

Publishing Details

Publisher Cambridge University Press
Imprint Cambridge University Press
Publication Date 20 September 2007
Publication Country United Kingdom

Description

The quest to understand the condensation of proteins from solutions is a rapidly evolving field. The purpose of this book is to bring to an interdisciplinary audience the state-of-the-art in current research. The first part of the book deals with issues related to the production of high quality protein crystals from solution. Since protein function is determined by structure, high quality protein crystals must be grown in order to determine their structure by X-ray crystallography. The book also discusses diseases that occur due to undesired protein condensation, an increasingly important subject. Examples include sickle cell anemia, cataracts and Alzheimer's disease. Current experimental and theoretical work on these diseases is discussed, which seeks understanding at a fundamental, molecular level, to prevent the undesired condensation from occurring. The book, containing color plate sections, is suitable for graduate students and academic researchers in physics, chemistry, structural biology, protein crystallography and medicine.

Author Biography

J. D. Gunton is Joseph A. Waldschmitt Professor of Physics at Lehigh University in Pennsylvania. He is the author of approximately 200 articles in refereed journals on equilibrium and nonequilibrium phase transitions. He is a Rhodes Scholar and a Danforth Fellow, and a Fellow of the American Physical Society. A. Shiryayev is a doctoral candidate at Lehigh University. He has already published several refereed articles that deal with the condensation of globular proteins. D. L. Pagan received is PhD degree from Lehigh University in 2005. He has authored several refereed articles on the condensation of globular proteins.

Reviews

'... the text covers just about anything a researcher would need to know of the many research areas of protein crystallisation. From statistical tests to theoretical models and mathematics, Gunton et al. appear to include the lot.' Journal of Biological Education