After Professor X's death, Captain America creates a new Avengers unit comprised of Avengers and X-Men, humans and mutants working together. But the Red Skull has plans to destroy all mutants - and when he exhumes Xavier's telepathic brain, he just might be able to do it! Can the new squad triumph over the Skull's bizarre S-Men? Meanwhile, the Apocalypse Twins arrive, with shocking plans for the future! Collecting: Uncanny Avengers 1-25, 8AU, Annual 1